Buy Methocarbamol (Robaxin) online

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Indications and usage:

Robaxin (Methocarbamol) 500 mg and 750 mg tablets are indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute, painful musculoskeletal conditions. The mode of action of methocarbamol has not been clearly identified, but may be related to its sedative properties. Methocarbamol does not directly relax tense skeletal muscles in man.


Dosage and administration:

Robaxin (Methocarbamol) 500 mg for adults

Initial dosage: 3 tablets q.i.d.
Maintenance dosage: 2 tablets q.i.d.

Robaxin-750 (Methocarbamol) 750 mg for adults

Initial dosage: 2 tablets q.i.d.
Maintenance dosage: 1 tablet q.4h. or 2 tablets t.i.d.

Six grams a day are recommended for the first 48 to 72 hours of treatment. (For severe conditions 8 grams a day may be administered). Thereafter, the dosage can usually be reduced to approximately 4 grams a day.


Overdosage:

Limited information is available on the acute toxicity of methocarbamol. Overdose of Robaxin is frequently in conjunction with alcohol or other CNS depressants and includes the following symptoms: nausea, drowsiness, blurred vision, hypotension, seizures, and coma. In post-marketing experience, deaths have been reported with an overdose of methocarbamol alone or in the presence of other CNS depressants, alcohol or psychotropic drugs.

Treatment

Management of overdose includes symptomatic and supportive treatment. Supportive measures include maintenance of an adequate airway, monitoring urinary output and vital signs, and administration of intravenous fluids if necessary. The usefulness of hemodialysis in managing overdose is unknown.


Dosage forms and strengths:

Robaxin is available as a light orange, round, film-coated tablet containing 500 mg of methocarbamol, USP for oral administration. The inactive ingredients present are corn starch, FD&C Yellow 6, hydroxypropyl cellulose, hypromellose, magnesium stearate, polysorbate 20, povidone, propylene glycol, saccharin sodium, sodium lauryl sulfate, sodium starch glycolate, stearic acid, titanium dioxide.


Contraindications:

Robaxin (Methocarbamol) tablets are contraindicated in patients hypersensitive to methocarbamol or to any of the tablet components.


Warnings:

Since methocarbamol may possess a general CNS depressant effect, patients receiving Robaxin should be cautioned about combined effects with alcohol and other CNS depressants. Safe use of Methocarbamol (Robaxin) pills has not been established with regard to possible adverse effects upon fetal development. There have been reports of fetal and congenital abnormalities following in utero exposure to methocarbamol. Therefore, Robaxin should not be used in women who are or may become pregnant and particularly during early pregnancy unless in the judgment of the physician the potential benefits outweigh the possible hazards.

Use in activities requiring mental alertness

Methocarbamol may impair mental and/or physical abilities required for performance of hazardous tasks, such as operating machinery or driving a motor vehicle. Patients should be cautioned about operating machinery, including automobiles, until they are reasonably certain that methocarbamol therapy does not adversely affect their ability to engage in such activities.


Precautions:

Drug/laboratory test interactions

Methocarbamol may cause a color interference in certain screening tests for 5-hydroxyindoleacetic acid (5-HIAA) using nitrosonaphthol reagent and in screening tests for urinary vanillylmandelic acid (VMA) using the Gitlow method.

Carcinogenesis, mutagenesis, impairment of fertility

Long-term studies to evaluate the carcinogenic potential of methocarbamol have not been performed. No studies have been conducted to assess the effect of Methocarbamol (Robaxin) on mutagenesis or its potential to impair fertility.


Adverse reactions, side effects:

Adverse reactions reported coincident with the administration of methocarbamol include:

Body as a whole: anaphylactic reaction, angioneurotic edema, fever, headache.
Cardiovascular system: bradycardia, flushing, hypotension, syncope, thrombophlebitis.
Digestive system: dyspepsia, jaundice (including cholestatic jaundice), nausea and vomiting.
Hemic and lymphatic system: leukopenia.
Immune system: hypersensitivity reactions.
Nervous system: amnesia, confusion, diplopia, dizziness or lightheadedness, drowsiness, insomnia, mild muscular incoordination, nystagmus, sedation, seizures (including grand mal), vertigo.
Skin and special senses: blurred vision, conjunctivitis, nasal congestion, metallic taste, pruritus, rash, urticaria.


Drug interactions:

Methocarbamol may inhibit the effect of pyridostigmine bromide. Therefore, methocarbamol should be used with caution in patients with myasthenia gravis receiving anticholinesterase agents.

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    Use in specific populations:

    Pregnancy

    Teratogenic effects. Pregnancy Category C. Animal reproduction studies have not been conducted with methocarbamol. It is also not known whether methocarbamol can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Robaxin should be given to a pregnant woman only if clearly needed.

    Safe use of Robaxin has not been established with regard to possible adverse effects upon fetal development. There have been reports of fetal and congenital abnormalities following in utero exposure to methocarbamol. Therefore, this medication should not be used in women who are or may become pregnant and particularly during early pregnancy unless in the judgment of the physician the potential benefits outweigh the possible hazards.

    Nursing mothers

    Methocarbamol and/or its metabolites are excreted in the milk of dogs; however, it is not known whether methocarbamol or its metabolites are excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Robaxin is administered to a nursing woman.

    Pediatric use

    Safety and effectiveness of Robaxin in pediatric patients below the age of 16 have not been established.


    Information for patients:

    Patients should be cautioned that methocarbamol may cause drowsiness or dizziness, which mayimpair their ability to operate motor vehicles or machinery.

    Because methocarbamol may possess a general CNS-depressant effect, patients should be cautioned about combined effects with alcohol and other CNS depressants.


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    Here is a list of popular medications containing methocarbamol as a main active pharmaceutical ingredient; their trade names, forms, doses, companies - manufacturers, distributors, suppliers, researchers and developers:

    Trade name of the drug Pharmaceutical forms and doses Companies
    Bigomet
  • Tablets; Oral; Methocarbamol 250 mg
  • Tablets; Oral; Methocarbamol 500 mg
  • Tablets; Oral; Methocarbamol 750 mg
  • Aristo Pharmaceuticals
  • Otsira Genetica
  • Lumirelax
  • Cream; Topical; Methocarbamol 10%
  • Tabsule; Oral; Methocarbamol 500 mg
  • Tradiphar Laboratoire
  • Alpharma
  • Juvise Pharmaceuticals Laboratories
  • Myomethol
  • Tablets; Oral; Methocarbamol 500 mg
  • R.X. Company
  • AustraPharm
  • Hind Wing
  • Medi Myanmar Group
  • Minh Tien Pharmaceutical
  • Ortoton
  • Tablets, Film-Coated; Oral; Methocarbamol 750 mg
  • Bastian-Werk
  • Recordati
  • Robaxin
  • Granules for Solution; Oral; Methocarbamol 900 mg / g
  • Injectable; Injection; Methocarbamol 100 mg / ml
  • Tablets; Oral; Methocarbamol 500 mg
  • Tablets; Oral; Methocarbamol 750 mg
  • Pfizer
  • Actient Pharmaceuticals
  • Almirall
  • ASKA Pharmaceutical
  • Aspen Pharmacare
  • Auxilium Pharmaceuticals
  • Baxter
  • Faes Farma
  • Ipsen Pharma
  • Schwarz Pharma
  • Shire
  • U.S. Summit
  • West-Ward Pharmaceuticals
  • Wyeth
  • Robinax
  • Injectable; Injection; Methocarbamol 100 mg / ml
  • Tablets; Oral; Methocarbamol 500 mg
  • Khandelwal Laboratories
  • Ni Lay Naing
  • Xenon Pharmaceuticals